Hoffman Donald R
Brody School of Medicine at East Carolina University, Greenville, North Carolina 27834, USA.
Curr Opin Allergy Clin Immunol. 2008 Aug;8(4):338-42. doi: 10.1097/ACI.0b013e3283036a7d.
Modern techniques in genomic and protein research are applied to the study of stinging and biting insect allergens.
Three-dimensional structures of additional insect venom and salivary allergens have been determined. An approach to determining B-cell epitopes has been used for hyaluronidase. A number of new venom and salivary allergens have been characterized. The structures and significance of several insect allergens have been updated. Investigations continue into distinguishing venom crossreactivity from multiple sensitization. Further studies are clarifying the significance of carbohydrate epitopes. Genomic and proteomic techniques are being used in the investigation of proteins and peptides in insect venom and saliva.
The nature of venom crossreactivity and the B-cell and T-cell epitope structures of insect venom and salivary allergens are beginning to be elucidated.
基因组学和蛋白质研究的现代技术被应用于刺叮昆虫过敏原的研究。
已确定了更多昆虫毒液和唾液过敏原的三维结构。一种确定B细胞表位的方法已用于透明质酸酶。一些新的毒液和唾液过敏原已得到鉴定。几种昆虫过敏原的结构和意义已得到更新。关于区分毒液交叉反应性和多重致敏的研究仍在继续。进一步的研究正在阐明碳水化合物表位的意义。基因组学和蛋白质组学技术正被用于研究昆虫毒液和唾液中的蛋白质和肽。
毒液交叉反应性的本质以及昆虫毒液和唾液过敏原的B细胞和T细胞表位结构正开始得到阐明。
