Rabinovitch Marlene
Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305-5162, USA.
J Clin Invest. 2008 Jul;118(7):2372-9. doi: 10.1172/JCI33452.
Recent investigations have suggested that it might be possible to reverse the pathology of pulmonary arterial hypertension (PAH), a disorder that can be rapidly progressive and fatal despite current treatments including i.v. prostacyclin. This review will address the cellular and molecular processes implicated in clinical, genetic, and experimental studies as underlying the pulmonary vascular abnormalities associated with PAH. Emerging treatments are aimed at inducing apoptosis of abnormal vascular cells that obstruct blood flow and at promoting regeneration of "lost" distal vasculature.
近期研究表明,肺动脉高压(PAH)的病理状况或许有可能被逆转。尽管目前有包括静脉注射前列环素在内的治疗方法,但PAH这种疾病仍可能迅速发展并导致死亡。本综述将探讨临床、遗传学和实验研究中所涉及的细胞与分子过程,这些过程被认为是PAH相关肺血管异常的潜在原因。新兴的治疗方法旨在诱导阻碍血流的异常血管细胞凋亡,并促进“缺失”的远端脉管系统再生。