Song Mengyang, Liu Bin, Wang Haiou, Sun Wei
Department of Cardiology The Second Hospital of Jilin University Changchun China.
MedComm (2020). 2025 Jul 1;6(7):e70269. doi: 10.1002/mco2.70269. eCollection 2025 Jul.
Traditionally regarded as a metabolic waste product, lactic acid is now recognized as a crucial molecule in energy metabolism and signal transduction. It regulates various biological processes, including intracellular inflammation and immune responses. Notably, a novel epigenetic modification, lactylation, which is directly linked to lactic acid, was first identified by Professor Zhao Yingming's team in 2019. Lactylation influences gene expression and is associated with inflammation, cancer, and ischemic disease. Despite its potential significance, the precise mechanisms by which lactylation regulates gene expression remain unclear, and its implications in cardiovascular diseases are not yet fully understood. This review elucidates the relationship between lactic acid metabolism and cellular functions, highlighting its significant biological roles. This review provides a comprehensive analysis of the mechanistic role of lactylation in disease progression. It synthesizes research findings and emerging trends concerning lactic acid production and lactylation in the context of cardiovascular diseases. We explored potential therapeutic agents targeting lactylation and identified prospective treatment targets, offering novel insights into and directions for intervention strategies related to lactic acid production and lactylation. Ultimately, this review aims to pave the way for new therapeutic and research avenues in cardiovascular diseases.
乳酸传统上被视为一种代谢废物，现在被认为是能量代谢和信号转导中的关键分子。它调节各种生物过程，包括细胞内炎症和免疫反应。值得注意的是，2019年赵英明教授团队首次发现了一种与乳酸直接相关的新型表观遗传修饰——乳酰化。乳酰化影响基因表达，并与炎症、癌症和缺血性疾病有关。尽管其具有潜在的重要意义，但乳酰化调节基因表达的精确机制仍不清楚，其在心血管疾病中的意义也尚未完全了解。本综述阐明了乳酸代谢与细胞功能之间的关系，突出了其重要的生物学作用。本综述全面分析了乳酰化在疾病进展中的机制作用。它综合了心血管疾病背景下有关乳酸产生和乳酰化的研究结果及新趋势。我们探索了针对乳酰化的潜在治疗药物，并确定了潜在的治疗靶点，为与乳酸产生和乳酰化相关的干预策略提供了新的见解和方向。最终，本综述旨在为心血管疾病的新治疗和研究途径铺平道路。
