Penzes Peter, Jones Kelly A
Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Trends Neurosci. 2008 Aug;31(8):419-27. doi: 10.1016/j.tins.2008.06.001. Epub 2008 Jul 1.
Changes in the structure and function of dendritic spines contribute to numerous physiological processes such as synaptic transmission and plasticity, as well as behavior, including learning and memory. Moreover, altered dendritic spine morphogenesis and plasticity is an endophenotype of many neurodevelopmental and neuropsychiatric disorders. Hence, the molecular mechanisms that control spine plasticity and pathology have been under intense investigation over the past few years. A series of recent studies has improved our understanding of spine dynamics by establishing kalirin-7 as an important regulator of dendritic spine development as well as structural and functional plasticity, providing a model for the molecular control of structural plasticity and implicating kalirin-7 in synaptic pathology in several disorders including schizophrenia and Alzheimer's disease.
树突棘的结构和功能变化有助于多种生理过程,如突触传递和可塑性,以及行为,包括学习和记忆。此外,树突棘形态发生和可塑性的改变是许多神经发育和神经精神疾病的一种内表型。因此,在过去几年中,控制棘突可塑性和病理学的分子机制一直受到深入研究。最近的一系列研究通过将kalirin-7确立为树突棘发育以及结构和功能可塑性的重要调节因子,增进了我们对棘突动力学的理解,为结构可塑性的分子控制提供了一个模型,并表明kalirin-7在包括精神分裂症和阿尔茨海默病在内的几种疾病的突触病理学中起作用。