新型苯氧乙酰胺衍生物的合成与抗菌活性评价

Synthesis and antimicrobial evaluation of new phenoxyacetamide derivatives.

作者信息

Raffa D, Migliara O, Daidone G, Maggio B, Schillaci D

机构信息

Università degli Studi di Palermo, Dipartimento di Chimica e Tecnologie Farmaceutiche, via Archirafi 32, 90123 Palermo, Italy.

出版信息

Boll Chim Farm. 2002 Jan-Feb;141(1):3-7.

PMID:12064055

Abstract

New N-(5-methylisoxazol-3-yl)-2 or 3 or 4-(phenoxyacetamido)benzamides 6a-t were synthesized and tested for their in vitro antimicrobial activity against gram positive (Staphylococcus aureus ATCC 25923) and gram negative (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853) bacteria as well as fungi (Candida albicans ATCC 10231, Candida tropicalis ATCC 13803 and Cryptococcus neoformans ATCC 90112). Compounds 6 were devoid of antibacterial as well as antifungal activities at maximum tested concentrations of 50 micrograms/ml for bacteria and 100 micrograms/ml for yeast.

摘要

合成了新型N-(5-甲基异恶唑-3-基)-2或3或4-(苯氧基乙酰胺基)苯甲酰胺6a - t，并测试了它们对革兰氏阳性菌(金黄色葡萄球菌ATCC 25923)、革兰氏阴性菌(大肠杆菌ATCC 25922和铜绿假单胞菌ATCC 27853)以及真菌(白色念珠菌ATCC 10231、热带念珠菌ATCC 13803和新型隐球菌ATCC 90112)的体外抗菌活性。在对细菌最高测试浓度为50微克/毫升、对酵母最高测试浓度为100微克/毫升时，化合物6没有抗菌和抗真菌活性。