新型 2,4,6-三嗪衍生物的合成及抗菌活性评价。
Synthesis and biological evaluation of novel 2,4,6-triazine derivatives as antimicrobial agents.
机构信息
PG Department of Chemistry and Research Center, SCS College, Omerga, India.
出版信息
Bioorg Med Chem Lett. 2012 Aug 1;22(15):5075-7. doi: 10.1016/j.bmcl.2012.05.111. Epub 2012 Jun 9.
A series of 2,4,6-trisubstituted [1,3,5]triazines were synthesized and evaluated for their antimicrobial activity against two representative Gram-positive, Gram-negative bacteria and two fungi. Biological data revealed that among all the compounds screened, compounds 3f, 3g, 3h, 3i, 3m, 3o and 3p found to have promising antimicrobial activity against all the selected pathogenic bacteria and fungi. Out of the synthesized compounds seven analogues have shown MIC in the range of 6.25-12.5 μg/mL. These compounds were generally nontoxic and may prove useful as antimicrobial agents.
合成了一系列 2,4,6-三取代的[1,3,5]三嗪，并评估了它们对两种代表性的革兰氏阳性、革兰氏阴性细菌和两种真菌的抗菌活性。生物数据显示，在所筛选的所有化合物中，化合物 3f、3g、3h、3i、3m、3o 和 3p 对所有选定的致病菌和真菌表现出有希望的抗菌活性。在所合成的化合物中，有七种类似物的 MIC 范围在 6.25-12.5μg/mL 之间。这些化合物通常没有毒性，可能可用作抗菌剂。
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