向感染HIV的儿童接种减毒活疫苗和灭活三价流感疫苗后，活疫苗病毒的排出、比较安全性及流感特异性抗体反应
Shedding of live vaccine virus, comparative safety, and influenza-specific antibody responses after administration of live attenuated and inactivated trivalent influenza vaccines to HIV-infected children.
作者信息
Levin Myron J, Song Lin-Ye, Fenton Terrence, Nachman Sharon, Patterson Julie, Walker Robert, Kemble George, Allende Maria, Hultquist Micki, Yi Tingting, Nowak Barbara, Weinberg Adriana
机构信息
University of Colorado School of Medicine, Aurora, CO 80045-0508, United States.
出版信息
Vaccine. 2008 Aug 5;26(33):4210-7. doi: 10.1016/j.vaccine.2008.05.054. Epub 2008 Jun 10.
Abstract
HIV-infected children (N=243), >or=5 to <18 years old, receiving stable antiretroviral therapy, were stratified by immunologic status and randomly assigned to receive intranasal live attenuated influenza vaccine (LAIV) or intramuscular trivalent inactivated influenza vaccine (TIV). The safety profile after LAIV or TIV closely resembled the previously reported tolerability to these vaccines in children without HIV infection. Post-vaccination hemagglutination inhibition (HAI) antibody responses and shedding of LAIV virus were also similar, regardless of immunological stratum, to antibody responses and shedding previously reported for children without HIV infection. LAIV should be further evaluated for a role in immunizing HIV-infected children.
摘要
243名年龄在5岁及以上至18岁以下、接受稳定抗逆转录病毒治疗的HIV感染儿童，根据免疫状态进行分层，并随机分配接受鼻内减毒活流感疫苗（LAIV）或肌肉注射三价灭活流感疫苗（TIV）。LAIV或TIV接种后的安全性与先前报道的未感染HIV儿童对这些疫苗的耐受性非常相似。无论免疫分层如何，接种疫苗后的血凝抑制（HAI）抗体反应和LAIV病毒排出情况也与先前报道的未感染HIV儿童的抗体反应和病毒排出情况相似。LAIV在免疫HIV感染儿童中的作用应进一步评估。
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