Skinnider L F, Ghadially F N
Arch Pathol Lab Med. 1976 Nov;100(11):601-5.
Bone marrow from a patient with bilateral staphylococcal bronchopneumonia who was treated with large doses of chloramphenicol was examined with the electron microscope. Our study supports the currently accepted concept that this drug depresses protein synthesis in mitochondria as it does in bacteria, since numerous alterations of mitochondrial morphology were encountered. These include (1) swollen mitochondria; (2) mitochondria with ruptured envelope; (3) mitochondria with longitudinally oriented cristae; (4) "ring" mitochondria; and (5) mitochondria with intramatrical iron deposits. The electron microscopical study discloses that the well documented vacuoles seen in marrow cells on light microscopy after treatment with this drug represent lipid droplets.
对一名双侧葡萄球菌性支气管肺炎患者的骨髓进行了电子显微镜检查，该患者曾接受大剂量氯霉素治疗。我们的研究支持目前公认的观点，即这种药物如同在细菌中一样，会抑制线粒体中的蛋白质合成，因为观察到线粒体形态有许多改变。这些改变包括：（1）线粒体肿胀；（2）线粒体包膜破裂；（3）嵴呈纵向排列的线粒体；（4）“环状”线粒体；（5）基质内有铁沉积的线粒体。电子显微镜研究表明，用该药治疗后在光学显微镜下骨髓细胞中所见的有充分记录的空泡代表脂滴。
