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在2'3'-双脱氧胞苷存在的情况下，与线粒体DNA减少和线粒体功能受损相关的超微结构变化。

Ultrastructural changes associated with reduced mitochondrial DNA and impaired mitochondrial function in the presence of 2'3'-dideoxycytidine.

作者信息

Lewis L D, Hamzeh F M, Lietman P S

机构信息

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.

出版信息

Antimicrob Agents Chemother. 1992 Sep;36(9):2061-5. doi: 10.1128/AAC.36.9.2061.

DOI:10.1128/AAC.36.9.2061
PMID:1329643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC192440/
Abstract

Incubation of Molt-4 cells in 4 microM 2'3'-dideoxycytidine did not produce a significant change in the mitochondrial ultrastructure after 4 days; however, by 12 days, the mitochondrial ultrastructure was distorted, with condensed cristae or vacuolization, or both. Concentration-dependent decreases in both cell growth (mean 50% inhibitory concentration, 4.70 +/- 0.5 microM) and mitochondrial DNA content (mean 50% inhibitory concentration, 0.46 +/- 0.06 microM) occurred after incubation with 2'3'-dideoxycytidine for 4 days.

摘要

将Molt-4细胞在4微摩尔的2'3'-二脱氧胞苷中培养4天后，线粒体超微结构未发生显著变化；然而，到12天时，线粒体超微结构出现扭曲，有嵴浓缩或空泡化，或两者皆有。用2'3'-二脱氧胞苷培养4天后，细胞生长（平均50%抑制浓度，4.70±0.5微摩尔）和线粒体DNA含量（平均50%抑制浓度，0.46±0.06微摩尔）均出现浓度依赖性下降。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e82/192440/6a1f262bbca5/aac00043-0296-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e82/192440/fc0a5a1e6d26/aac00043-0294-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e82/192440/85e41b910da5/aac00043-0295-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e82/192440/0fe6745ebad1/aac00043-0296-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e82/192440/6a1f262bbca5/aac00043-0296-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e82/192440/fc0a5a1e6d26/aac00043-0294-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e82/192440/9ca078c01464/aac00043-0295-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e82/192440/85e41b910da5/aac00043-0295-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e82/192440/0fe6745ebad1/aac00043-0296-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e82/192440/6a1f262bbca5/aac00043-0296-b.jpg

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