心肌的胚胎发生。
Embryogenesis of the heart muscle.
作者信息
Sedmera David, McQuinn Tim
机构信息
Institute of Animal Physiology and Genetics, Prague, Czech Republic.
出版信息
Heart Fail Clin. 2008 Jul;4(3):235-45. doi: 10.1016/j.hfc.2008.02.007.
Abstract
This article concerns the development of myocardial architecture--crucial for contractile performance of the heart and its conduction system, essential for generation and coordinated spread of electrical activity. Topics discussed include molecular determination of cardiac phenotype (contractile and conducting), remodeling of ventricular wall architecture and its blood supply, and relation of trabecular compaction to noncompaction cardiomyopathy. Illustrated are the structure and function of the tubular heart, time course of trabecular compaction, and development of multilayered spiral systems of the compact layer.
摘要
本文关注心肌结构的发育——这对心脏的收缩性能及其传导系统至关重要，是电活动产生和协调传播所必需的。讨论的主题包括心脏表型（收缩和传导）的分子决定因素、心室壁结构及其血液供应的重塑，以及小梁致密化与非致密化心肌病的关系。文中展示了管状心脏的结构和功能、小梁致密化的时间进程，以及致密层多层螺旋系统的发育。
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