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Nicotinic receptor blockade therapy and smoking cessation.

作者信息

Clarke P B

机构信息

Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada.

出版信息

Br J Addict. 1991 May;86(5):501-5. doi: 10.1111/j.1360-0443.1991.tb01797.x.

DOI:10.1111/j.1360-0443.1991.tb01797.x
PMID:1859912
Abstract

Smoking is a behaviour with a significant conditioned component. Attempts to quit will likely fail unless the effects of primary and secondary reinforcers are extinguished. Current smoking cessation methods scarcely address this issue, which may explain why they meet with little success in the long term. In contrast, the administration of centrally-active nicotinic receptor antagonists should provide a means of extinguishing both primary and secondary reinforcers associated with smoking. Thus, nicotine blockade therapy presents a promising new approach to smoking cessation.

摘要

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