Meyer Haakon E, Søgaard Anne Johanne, Falch Jan A, Jørgensen Lone, Emaus Nina
Section for Preventive Medicine and Epidemiology, Institute of General Practice and Community Medicine, University of Oslo, Oslo, Norway.
Am J Epidemiol. 2008 Aug 15;168(4):454-60. doi: 10.1093/aje/kwn151. Epub 2008 Jul 2.
The purpose of this study was to assess the effect of weight in middle-aged men and subsequent weight change on the risk of osteoporosis three decades later. The authors utilized data from 1,476 Norwegian men participating in two health screenings in Oslo (1972-1973 and 2000-2001) and Tromsø (1974-1975 and 2001). Height and weight were measured at baseline and follow-up. Total hip bone mineral density (BMD) was assessed at follow-up by dual energy x-ray absorptiometry. Baseline body mass index (BMI) was positively related to BMD three decades later. Subsequent weight change was also strongly related to BMD, and the proportion of persons with osteoporosis decreased from 15.1% among those who lost >or=10% of their body weight to 0.6% among those who gained >or=10% of their body weight. Excluding participants with medical conditions did not change the association between weight change and BMD. Taking both BMI and weight change into account, the prevalence of osteoporosis in the lowest quarter of baseline BMI was 31% (95% confidence interval: 24, 37) in persons losing >or=5% of their weight and 4% (95% confidence interval: 1, 7) in persons gaining >or=5% of their weight. In this cohort of middle-aged men, low baseline BMI and weight loss during the following three decades were both strongly and negatively related to total hip BMD.
本研究的目的是评估中年男性的体重及随后的体重变化对三十年后骨质疏松症风险的影响。作者利用了来自1476名挪威男性的数据，这些男性参与了在奥斯陆（1972 - 1973年和2000 - 2001年）以及特罗姆瑟（1974 - 1975年和2001年）进行的两次健康筛查。在基线和随访时测量了身高和体重。随访时通过双能X线吸收法评估了全髋骨矿物质密度（BMD）。三十年后，基线体重指数（BMI）与BMD呈正相关。随后的体重变化也与BMD密切相关，骨质疏松症患者的比例从体重减轻≥10%的人群中的15.1%降至体重增加≥10%的人群中的0.6%。排除患有疾病的参与者并没有改变体重变化与BMD之间的关联。综合考虑BMI和体重变化，在基线BMI最低的四分之一人群中，体重减轻≥5%的人群骨质疏松症患病率为31%（95%置信区间：24, 37），体重增加≥5%的人群中为4%（95%置信区间：1, 7）。在这一中年男性队列中，低基线BMI和随后三十年中的体重减轻均与全髋BMD呈强烈负相关。
