Lyons M K, Anderson R E, Meyer F B
Department of Neurological Surgery, Mayo Clinic, Rochester, MN 55905.
Brain Res. 1991 Apr 5;545(1-2):339-42. doi: 10.1016/0006-8993(91)91310-w.
This experiment tested the hypothesis that corticotropin-releasing factor (CRF) contributes to hippocampal ischemic injury. The antagonist to CRF (alpha-CRF) was administered intraventricularly 15 min prior to 10 min of transient forebrain ischemia in the Wistar rat. alpha-CRF demonstrated a neuroprotective effect in a dose-dependent manner most notable in CA1. There was also an increase in postischemic EEG recovery. It is postulated that CRF contributes to hippocampal ischemic injury through increased neuronal activity.
本实验检验了促肾上腺皮质激素释放因子（CRF）导致海马体缺血性损伤的假说。在Wistar大鼠短暂性前脑缺血10分钟前15分钟，经脑室注射CRF拮抗剂（α-CRF）。α-CRF呈剂量依赖性地表现出神经保护作用，在CA1区最为显著。缺血后脑电图恢复也有所增加。据推测，CRF通过增加神经元活动导致海马体缺血性损伤。
