Rothwell N J
Department of Physiological Sciences, University of Manchester, United Kingdom.
Horm Metab Res. 1990 Dec;22(12):616-8. doi: 10.1055/s-2007-1004986.
Central (intracerebroventricular) injections of PGE2, PGF2 alpha caused dose dependent increases in oxygen consumption (VO2) and colonic temperature in conscious rats. The effects of combined injection of maximal doses of CRF and PGE2 were additive, whereas PGF2 alpha and CRF were not. A CRF receptor antagonist, (alpha helical CRF 9-41, 25 micrograms icv) markedly inhibited the effects of PGF2 alpha on VO2 and temperature, but did not affect the actions of PGE2. These data indicate that PGF2 alpha and PGE2 stimulate thermogenesis by two different mechanisms, the former depending on CRF release. PGF2 alpha may be involved in the thermogenic actions of interleukin-1 beta which is also a potent thermogenic agent acting via CRF.
向清醒大鼠脑室内注射前列腺素E2（PGE2）、前列腺素F2α（PGF2α）可使耗氧量（VO2）和结肠温度呈剂量依赖性升高。联合注射最大剂量的促肾上腺皮质激素释放因子（CRF）和PGE2的作用具有相加性，而PGF2α和CRF则不然。一种CRF受体拮抗剂（α螺旋CRF 9 - 41，25微克，脑室内注射）可显著抑制PGF2α对VO2和体温的作用，但不影响PGE2的作用。这些数据表明，PGF2α和PGE2通过两种不同机制刺激产热，前者依赖于CRF释放。PGF2α可能参与白细胞介素 - 1β的产热作用，白细胞介素 - 1β也是一种通过CRF发挥作用的强效产热剂。
