亨廷顿舞蹈症患者移植后人类纹状体原基的发育
Development of human striatal anlagen after transplantation in a patient with Huntington's disease.
作者信息
Gallina Pasquale, Paganini Marco, Lombardini Letizia, Saccardi Riccardo, Marini Mirca, De Cristofaro Maria Teresa, Pinzani Pamela, Salvianti Francesca, Crescioli Clara, Di Rita Andrea, Bucciantini Sandra, Mechi Claudia, Sarchielli Erica, Moretti Marco, Piacentini Silvia, Gritti Gaetano, Bosi Alberto, Sorbi Sandro, Orlandini Giovanni, Vannelli Gabriella B, Di Lorenzo Nicola
机构信息
Department of Neurosurgery, University of Florence, Florence, Italy.
出版信息
Exp Neurol. 2008 Sep;213(1):241-4. doi: 10.1016/j.expneurol.2008.06.003. Epub 2008 Jun 14.
Replacement of damaged neuronal population by fetal tissue transplantation represents a potential treatment for neurodegenerative diseases. Consistent success has been achieved with fetal striatal transplantation in Huntington's disease animal models and patients. We report the neo-generation of metabolically active tissue with striatum-like imaging features after transplantation of striatal primordia in a patient with Huntington's disease. This study represents the first "in vivo" demonstration that a human striatal anlagen, transplanted into the adult human brain, is able to progress in its development and to generate a new anatomical structure in the host, without evidence of neoplasia or teratoma.
通过胎儿组织移植替代受损的神经元群体是神经退行性疾病的一种潜在治疗方法。在亨廷顿舞蹈病动物模型和患者中，胎儿纹状体移植已取得了持续的成功。我们报告了一名亨廷顿舞蹈病患者在接受纹状体原基移植后，出现了具有类似纹状体成像特征的代谢活跃组织的新生。这项研究首次“在体内”证明，移植到成人大脑中的人类纹状体原基能够在宿主中继续发育并生成新的解剖结构，且没有肿瘤形成或畸胎瘤的迹象。
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