Zhang L, Zhang Y, Xia Q, Zhao X M, Cai H X, Li D W, Yang X D, Wang K, Xia Z L
Research Institute of Life Science, Taishan Medical University,Taian, Shandong 271000, People's Republic of China.
Food Chem Toxicol. 2008 Sep;46(9):2996-3002. doi: 10.1016/j.fct.2008.05.040. Epub 2008 Jun 11.
Vanadium compounds have been well recognized for hypoglycemic effects, but questions remain on gastrointestinal disturbance and possible tissue vanadium accumulation thus slowing the acceptance of vanadium compounds as diabetic therapeutic agents. Our intestinal permeability and toxicity studies of vanadium compounds have suggested that the co-administration of vanadate with Salvia miltiorrhiza Bunge decoction could benefit the therapeutic use of hypoglycemic vanadium compounds. In the present paper, we tested the hypoglycemic effects of vanadate ingested in an aqueous extract of S. Bunge using a streptozocin (STZ)-induced diabetic rat model. Oral administration of vanadate in S. Bunge herbal decoction produced a stable (free of hypoglycemic shock) and long-lasting ( approximately 70day) control of blood glucose status. Effective protection of animal organs from hyperglycemic damage was also observed. As expected, the herbal extract significantly alleviated vanadium toxicity, i.e. GI stress and metal accumulation. In addition, the result suggesting that vanadium-induced amelioration of the diabetic state appears to be secondary to the preservation of a functional portion of the pancreatic beta-cells which initially survived STZ-toxicity. These studies provide new insight into the therapeutic treatment of diabetics with vanadium compounds.
钒化合物的降血糖作用已得到广泛认可，但关于胃肠道紊乱以及钒在组织中可能的蓄积问题依然存在，这使得钒化合物作为糖尿病治疗药物的接受度受到影响。我们对钒化合物进行的肠道通透性和毒性研究表明，钒酸盐与丹参水煎剂联合使用可能有益于降血糖钒化合物的治疗应用。在本文中，我们使用链脲佐菌素（STZ）诱导的糖尿病大鼠模型，测试了摄入丹参水提取物中钒酸盐的降血糖作用。口服丹参草药煎剂中的钒酸盐可使血糖水平得到稳定（无低血糖休克）且持久（约70天）的控制。还观察到对动物器官免受高血糖损伤的有效保护作用。正如预期的那样，草药提取物显著减轻了钒的毒性，即胃肠道应激和金属蓄积。此外，结果表明钒诱导的糖尿病状态改善似乎继发于对最初在STZ毒性中存活下来的胰腺β细胞功能部分的保留。这些研究为用钒化合物治疗糖尿病提供了新的见解。
