Castro N, Toranzo A E, Núñez S, Magariños B
Departamento de Microbiología y Parasitología, Facultad de Biología-CIBUS and Instituto de Acuicultura, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
Fish Shellfish Immunol. 2008 Sep;25(3):208-12. doi: 10.1016/j.fsi.2008.05.008. Epub 2008 May 29.
Since 2004 Edwardsiella tarda has become one of the most important emerging pathogens in turbot aquaculture industry in Europe causing serious economic losses. Therefore, this study aimed to design an effective vaccination strategy to prevent edwardsiellosis in this fish species. Two vaccine formulations, an adjuvanted vaccine and an aqueous bacterin, and different routes of administration, bath and intraperitoneal injection (i.p.), were tested. The effectiveness of the different immunization strategies was evaluated in terms of relative percent survival (RPS) and antibody levels. On the basis of the results obtained we recommend the i.p. administration of a non-mineral oil adjuvanted vaccine via i.p., which confers RPS values over 90% at least 6 months post-vaccination.
自2004年以来，迟缓爱德华氏菌已成为欧洲大菱鲆水产养殖业中最重要的新兴病原体之一，造成了严重的经济损失。因此，本研究旨在设计一种有效的疫苗接种策略，以预防该鱼类的爱德华氏菌病。测试了两种疫苗制剂，一种佐剂疫苗和一种水剂菌苗，以及不同的给药途径，浸浴和腹腔注射（i.p.）。根据相对存活率（RPS）和抗体水平评估了不同免疫策略的有效性。根据所得结果，我们建议通过腹腔注射接种不含矿物油佐剂的疫苗，该疫苗在接种后至少6个月可使RPS值超过90%。
