[严重横纹肌溶解症揭示了一种与自身免疫性甲状腺功能减退相关的肌病]

[Severe rhabdomyolysis revealing a myopathy linked to autoimmune hypothyroidism].

作者信息

Mouzouri H, El Omri N, Sekkach Y, Frikh R, Nzambe C, Qacif H, Baizri H, Makouar F, Qatni M El, Belmejdoub G, Rkiouak F, Ghafir D, Ohayon V, Archane M I

出版信息

Ann Endocrinol (Paris). 2009 Mar;70(1):83-6. doi: 10.1016/j.ando.2008.05.001. Epub 2008 Jul 7.

DOI:10.1016/j.ando.2008.05.001

PMID:18603225

Abstract

While muscular manifestations are common of hypothyroidism, hypothyroid myopathy is most often limited to myalgia, muscular stiffness and cramps with, in some patients, elevated levels of muscle enzymes. We report two cases of rhabdomyolysis related to hypothyroid myopathy. One of the patients developed acute renal failure. Thyroid hormone replacement therapy improved thyroid and renal function with involution of rhabdomyolysis. Hypothyroidism appears to be an authentic cause of rhabdomyolysis and should be carefully ruled out in all patients with elevated serum levels of muscle enzymes.

摘要

虽然肌肉表现是甲状腺功能减退症的常见症状，但甲状腺功能减退性肌病通常仅限于肌痛、肌肉僵硬和痉挛，部分患者还伴有肌肉酶水平升高。我们报告了两例与甲状腺功能减退性肌病相关的横纹肌溶解症病例。其中一名患者发展为急性肾衰竭。甲状腺激素替代疗法改善了甲状腺和肾功能，横纹肌溶解症也随之消退。甲状腺功能减退似乎是横纹肌溶解症的一个真正病因，在所有肌肉酶血清水平升高的患者中都应仔细排除。