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横纹肌溶解症:他汀类药物治疗引发的桥本甲状腺炎罕见并发症。

Rhabdomyolysis: a rare complication of Hashimoto's thyroiditis precipitated by statin therapy.

作者信息

Peringat Jayameena, Manappallil Robin George, Karadan Ummer

机构信息

Department of Nephrology, Baby Memorial Hospital, Calicut, Kerala, India.

Department of Internal Medicine, Baby Memorial Hospital, Calicut, Kerala, India.

出版信息

BMJ Case Rep. 2018 Feb 12;2018:bcr-2017-223229. doi: 10.1136/bcr-2017-223229.

Abstract

Hashimoto's thyroiditis (HT) or chronic lymphocytic thyroiditis is the most common form of primary hypothyroidism. Muscular manifestations like weakness, pain, stiffness and elevated muscle enzymes have been noticed in hypothyroidism. Statins are also known to cause myositis and rhabdomyolysis. This is a case of a middle-aged man, on statin therapy, who presented with severe muscle aches and pain and was found to have rhabdomyolysis. Further evaluation revealed an underlying HT as the culprit for his condition. He was managed with intravenous fluids and levothyroxine along with cessation of statins, following which he improved.

摘要

桥本甲状腺炎(HT)或慢性淋巴细胞性甲状腺炎是原发性甲状腺功能减退最常见的形式。甲状腺功能减退时会出现如虚弱、疼痛、僵硬和肌肉酶升高之类的肌肉表现。他汀类药物也已知会引起肌炎和横纹肌溶解。这是一例正在接受他汀类药物治疗的中年男性病例,他出现了严重的肌肉酸痛,并被发现患有横纹肌溶解。进一步评估发现潜在的桥本甲状腺炎是其病情的罪魁祸首。对他采用静脉输液、左甲状腺素治疗,并停用他汀类药物,之后他病情好转。

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