Branski Ludwik K, Gauglitz Gerd G, Herndon David N, Jeschke Marc G
Department of Surgery, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX 77550, United States.
Burns. 2009 Mar;35(2):171-80. doi: 10.1016/j.burns.2008.03.009. Epub 2008 Jul 7.
Different therapies that effect wound repair have been proposed over the last few decades. This article reviews the emerging fields of gene and stem cell therapy in wound healing. Gene therapy, initially developed for treatment of congenital defects, is a new option for enhancing wound repair. In order to accelerate wound closure, genes encoding for growth factors or cytokines showed the greatest potential. The majority of gene delivery systems are based on viral transfection, naked DNA application, high pressure injection, or liposomal vectors. Embryonic and adult stem cells have a prolonged self-renewal capacity with the ability to differentiate into various tissue types. A variety of sources, such as bone marrow, peripheral blood, umbilical cord blood, adipose tissue, skin and hair follicles, have been utilized to isolate stem cells to accelerate the healing response of acute and chronic wounds. Recently, the combination of gene and stem cell therapy has emerged as a promising approach for treatment of chronic and acute wounds.
在过去几十年里，人们提出了不同的促进伤口修复的疗法。本文综述了基因和干细胞治疗在伤口愈合方面的新兴领域。基因治疗最初是为治疗先天性缺陷而开发的，是增强伤口修复的一种新选择。为了加速伤口闭合，编码生长因子或细胞因子的基因显示出最大的潜力。大多数基因递送系统基于病毒转染、裸DNA应用、高压注射或脂质体载体。胚胎干细胞和成体干细胞具有延长的自我更新能力，能够分化为各种组织类型。人们利用多种来源，如骨髓、外周血、脐带血、脂肪组织、皮肤和毛囊，来分离干细胞，以加速急慢性伤口的愈合反应。最近，基因和干细胞治疗的联合已成为治疗急慢性伤口的一种有前景的方法。
