用于递送生物活性因子以增强伤口愈合过程中真皮替代物血管生成的纳米材料。
Nanomaterials for the delivery of bioactive factors to enhance angiogenesis of dermal substitutes during wound healing.
作者信息
Weng Tingting, Wang Jialiang, Yang Min, Zhang Wei, Wu Pan, You Chuangang, Han Chunmao, Wang Xingang
机构信息
Department of Burns & Wound Care Centre, the Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou 310002, China.
Key Laboratory of The Diagnosis and Treatment of Severe Trauma and Burn of Zhejiang Province, Hangzhou 310002,China.
出版信息
Burns Trauma. 2022 Mar 22;10:tkab049. doi: 10.1093/burnst/tkab049. eCollection 2022.
Dermal substitutes provide a template for dermal regeneration and reconstruction. They constitutes an ideal clinical treatment for deep skin defects. However, rapid vascularization remains as a major hurdle to the development and application of dermal substitutes. Several bioactive factors play an important regulatory role in the process of angiogenesis and an understanding of the mechanism of achieving their effective delivery and sustained function is vital. Nanomaterials have great potential for tissue engineering. Effective delivery of bioactive factors (including growth factors, peptides and nucleic acids) by nanomaterials is of increasing research interest. This paper discusses the process of dermal substitute angiogenesis and the roles of related bioactive factors in this process. The application of nanomaterials for the delivery of bioactive factors to enhance angiogenesis and accelerate wound healing is also reviewed. We focus on new systems and approaches for delivering bioactive factors for enhancing angiogenesis in dermal substitutes.
皮肤替代物为皮肤再生和重建提供了一个模板。它们是治疗深度皮肤缺损的理想临床方法。然而，快速血管化仍然是皮肤替代物开发和应用的主要障碍。几种生物活性因子在血管生成过程中发挥着重要的调节作用，了解实现其有效递送和持续功能的机制至关重要。纳米材料在组织工程方面具有巨大潜力。通过纳米材料有效递送生物活性因子（包括生长因子、肽和核酸）越来越受到研究关注。本文讨论了皮肤替代物血管生成的过程以及相关生物活性因子在此过程中的作用。还综述了纳米材料在递送生物活性因子以增强血管生成和加速伤口愈合方面的应用。我们重点关注用于递送生物活性因子以增强皮肤替代物中血管生成的新系统和方法。
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