Saule H
II. Kinderklinik, Zentralklinikum Augsburg.
Dtsch Med Wochenschr. 1991 Aug 2;116(31-32):1191-4. doi: 10.1055/s-2008-1063735.
Two girls (aged 14 and 16 years) with type I diabetes were hospitalized with blood sugar levels of 394 and 319 mg/dl as well as HbA1 levels of 14.2 and 14.1%, respectively. In the first case it was the first sign of diabetes, in the other it was the result of a metabolic dysfunction with an injection abscess after ten years of the disease. After an initial substitution with regular insulin (subcutaneously in Case 1 [1.5-1.7 IU/kg daily for 3 days; in Case 2, continuous i.v. infusion [1.3 IU/kg daily] for 58 hours, followed by injections of appropriate mixtures of short and long-acting insulin) serum glucose levels were nearly always within normal range from the third day onward. Within 6 days of normal glucose levels being established hard pitting oedema, especially of the legs, developed in both girls, associated with a weight gain of 6.1 and 7.0 kg, respectively. Renal, hepatic and cardiovascular disease having been excluded the diagnosis of insulin-induced oedema was made. Within a further two weeks the oedema had disappeared without any specific treatment.
两名患有I型糖尿病的女孩（年龄分别为14岁和16岁）因血糖水平分别为394和319mg/dl以及糖化血红蛋白（HbA1）水平分别为14.2%和14.1%而住院。在第一例中，这是糖尿病的首发症状；在另一例中，这是患病十年后出现注射脓肿导致代谢功能障碍的结果。在最初用常规胰岛素替代治疗后（第一例皮下注射[每日1.5 - 1.7IU/kg，共3天]；第二例持续静脉输注[每日1.3IU/kg]58小时，随后注射短效和长效胰岛素的适当混合制剂），从第三天起血清葡萄糖水平几乎始终处于正常范围内。在血糖水平恢复正常的6天内，两名女孩均出现了严重的凹陷性水肿，尤其是腿部，体重分别增加了6.1kg和7.0kg。排除了肾脏、肝脏和心血管疾病后，做出了胰岛素性水肿的诊断。在接下来的两周内，水肿未经任何特殊治疗便消失了。
