Gao Xiangwei, Xu Zhengping
Research Center for Environmental Genomics, Bioelectromagnetics Laboratory, Zhejiang University School of Medicine, Hangzhou 310058, China.
Acta Biochim Biophys Sin (Shanghai). 2008 Jul;40(7):619-24. doi: 10.1111/j.1745-7270.2008.00442.x.
Angiogenin induces angiogenesis by activating vessel endothelial and smooth muscle cells and triggering a number of biological processes, including cell migration, invasion, proliferation, and formation of tubular structures. It has been reported that angiogenin plays its functions mainly through four pathways: (1) exerting its ribonucleolytic activity; (2) binding to membrane actin and then inducing basement membrane degradation; (3) binding to a putative 170-kDa protein and subsequently transducing signal into cytoplasm; and (4) translocating into the nucleus of target cells directly and then enhancing ribosomal RNA transcription. Angiogenin can also translocate into the nucleus of cancer cells and induces the corresponding cell proliferation. Furthermore, angiogenin has neuroprotective activities in the central nervous system and the loss of its function may be related to amyotrophic lateral sclerosis. This review intends to conclude the mechanisms underlying these actions of angiogenin and give a perspective on future research.
血管生成素通过激活血管内皮细胞和平滑肌细胞并触发一系列生物学过程来诱导血管生成，这些过程包括细胞迁移、侵袭、增殖以及管状结构的形成。据报道，血管生成素主要通过四条途径发挥其功能：（1）发挥其核糖核酸酶活性；（2）与膜肌动蛋白结合，进而诱导基底膜降解；（3）与一种假定的170 kDa蛋白结合，随后将信号转导至细胞质；（4）直接转运至靶细胞的细胞核，进而增强核糖体RNA转录。血管生成素还可转运至癌细胞的细胞核并诱导相应的细胞增殖。此外，血管生成素在中枢神经系统中具有神经保护活性，其功能丧失可能与肌萎缩侧索硬化症有关。本综述旨在总结血管生成素这些作用的潜在机制，并对未来研究进行展望。
