Labeur Marta, Paez-Pereda Marcelo, Arzt Eduardo, Stalla Günter K
Max Planck Institute of Psychiatry, Munich, Germany.
Rev Endocr Metab Disord. 2009 Jun;10(2):103-9. doi: 10.1007/s11154-008-9080-6. Epub 2008 Jul 7.
Cushing's disease is a severe clinical condition caused by hypersecretion of corticosteroids due to excessive ACTH secretion from a pituitary adenoma. This complex endocrine disorder still represents a major challenge for the physician in terms of efficient treatment. In the last years there was only little progress in elucidating the molecular mechanisms responsible for the constitutive and autonomous ACTH secretion of pituitary corticotrophinomas. As a consequence, no effective drug therapy is currently available, particularly if surgical excision is not successful. In the present article we examine recent studies that have investigated the therapeutic potential of retinoic acid receptors as nuclear receptor targets for the treatment of Cushing's disease. Retinoic acid is an efficient drug used for the treatment of different types of cancers and it proved to act in animal models of Cushing's disease. The efficiency of this treatment in patients with this disorder still needs to be tested in clinical trials.
库欣病是一种严重的临床病症，由垂体腺瘤过度分泌促肾上腺皮质激素（ACTH）导致皮质类固醇分泌过多引起。就有效治疗而言，这种复杂的内分泌紊乱对医生来说仍然是一项重大挑战。在过去几年中，在阐明垂体促肾上腺皮质激素瘤组成性和自主性ACTH分泌的分子机制方面进展甚微。因此，目前尚无有效的药物治疗方法，尤其是在手术切除不成功的情况下。在本文中，我们研究了最近的一些研究，这些研究探讨了视黄酸受体作为核受体靶点治疗库欣病的治疗潜力。视黄酸是一种用于治疗不同类型癌症的有效药物，并且已在库欣病动物模型中证明其有作用。这种治疗方法对该疾病患者的疗效仍需在临床试验中进行测试。
