以多相钯碳（Pd/C）为催化剂的无配体Sonogashira偶联反应。
Ligand-free Sonogashira coupling reactions with heterogeneous Pd/C as the catalyst.
作者信息
Mori Shigeki, Yanase Takayoshi, Aoyagi Satoka, Monguchi Yasunari, Maegawa Tomohiro, Sajiki Hironao
机构信息
Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 6-1, Mitahora-higashi 5-chome, Gifu, Japan.
出版信息
Chemistry. 2008;14(23):6994-9. doi: 10.1002/chem.200800387.
PMID:18604848
Abstract
A variety of aryl iodides were coupled with aromatic and aliphatic terminal alkynes to give the corresponding 1,2-disubstituted aromatic alkynes in good yields by using only 0.4 mol % of the heterogeneous 10 % Pd/C as the catalyst without a ligand, copper salt, or amine in an aqueous medium.
摘要
通过在水介质中仅使用0.4摩尔%的非均相10%钯碳作为催化剂，无需配体、铜盐或胺，多种芳基碘化物与芳香族和脂肪族末端炔烃偶联，以良好的产率得到相应的1,2-二取代芳香族炔烃。
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