钯催化的芳基碘化物与炔烃的无铜羰基化Sonogashira反应，以水为溶剂合成炔基酮和黄酮。
Pd-catalyzed copper-free carbonylative Sonogashira reaction of aryl iodides with alkynes for the synthesis of alkynyl ketones and flavones by using water as a solvent.
作者信息
Liang Bo, Huang Mengwei, You Zejin, Xiong Zhengchang, Lu Kui, Fathi Reza, Chen Jiahua, Yang Zhen
机构信息
Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, College of Chemistry, School of Pharmaceutical Science, ShenZhen Graduate School, Peking University, Beijing 100871, China.
出版信息
J Org Chem. 2005 Jul 22;70(15):6097-100. doi: 10.1021/jo050498t.
The Pd-catalyzed copper-free carbonylative Sonogashira coupling reaction to synthesize alkynyl ketones from terminal alkynes and aryl iodides was achieved by using water as a solvent. The reaction was carried out at room temperature under balloon pressure of CO with Et(3)N as a base. The developed method was successfully applied to the synthesis of flavones.
通过使用水作为溶剂，实现了钯催化的无铜羰基化Sonogashira偶联反应，该反应可由末端炔烃和芳基碘化物合成炔基酮。反应在室温下、CO气球压力下、以三乙胺作为碱进行。所开发的方法成功应用于黄酮类化合物的合成。
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