用于治疗炎症性眼病的生物制剂。
Biologic agents in the management of inflammatory eye diseases.
作者信息
Michalova Kira, Lim Lyndell
机构信息
Macular Research Unit, Centre for Eye Research Australia, 32 Gisborne Street, University of Melbourne, East Melbourne, Victoria 3002, Australia.
出版信息
Curr Allergy Asthma Rep. 2008 Jul;8(4):339-47. doi: 10.1007/s11882-008-0054-2.
Biologics are a new class of drugs that comprise recombinant cytokines and monoclonal antibodies directed against selected cell-surface markers. They include the tumor necrosis factor-alpha inhibitors infliximab, etanercept, and adalimumab; the antilymphocyte drugs rituximab and alemtuzumab; the interleukin-2 receptor blocker daclizumab; and recombinant interferon-alpha. This article reviews the rationale and current evidence for their use in uveitis, scleritis, and orbital inflammation.
生物制剂是一类新型药物，包括重组细胞因子和针对特定细胞表面标志物的单克隆抗体。它们包括肿瘤坏死因子-α抑制剂英夫利昔单抗、依那西普和阿达木单抗；抗淋巴细胞药物利妥昔单抗和阿仑单抗；白细胞介素-2受体阻滞剂达利珠单抗；以及重组干扰素-α。本文综述了它们在葡萄膜炎、巩膜炎和眼眶炎症中应用的基本原理和当前证据。
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