Crowell Christopher, Lyew Rachel Villacorta, Givens Melissa, Deering Shad H
Department of Emergency Medicine, Madigan Army Medical Center, Tacoma, WA 98431, USA.
Am J Emerg Med. 2008 Jul;26(6):735.e1-2. doi: 10.1016/j.ajem.2007.11.017.
Acetaminophen is one of the most common toxicities in pregnancy, thus providers should be aware of treatment options. We use a case presentation to demonstrate the successful use of a 20-hour protocol of intravenous N-acetylcysteine. A 26-year-old woman, gravid3para1102, at an estimated gestational age of 32 weeks 2 days presented with a reported ingestion of 9.75 g of acetaminophen 1.5 hours before arrival. The patient was treated with activated charcoal and intravenous N-acetylcysteine. After brief inpatient admission and management, the patient went on to deliver a full-term infant without further sequelae. Acetaminophen toxicity in pregnancy can be treated successfully with intravenous N-acetylcysteine if used in a timely manner with minimal adverse affects on the fetus and mother.
对乙酰氨基酚中毒是孕期最常见的毒性反应之一，因此医疗人员应了解其治疗方案。我们通过一个病例展示静脉注射N-乙酰半胱氨酸20小时方案的成功应用。一名26岁女性，孕3产1，孕龄估计为32周2天，在入院前1.5小时据称摄入了9.75克对乙酰氨基酚。患者接受了活性炭和静脉注射N-乙酰半胱氨酸治疗。经过短暂的住院治疗和管理，患者顺利产下一名足月婴儿，无进一步后遗症。孕期对乙酰氨基酚中毒若及时使用静脉注射N-乙酰半胱氨酸治疗，可成功治愈，且对胎儿和母亲的不良影响最小。
