靶向耐药性结肠癌的支架
Scaffold targeting drug-resistant colon cancers.
作者信息
Otrubova Katerina, McGuire Kathleen L, McAlpine Shelli R
机构信息
Department of Chemistry and Biochemistry, 5500 Campanile Road, San Diego State University, San Diego, California 92182-1030, USA.
出版信息
J Med Chem. 2007 May 3;50(9):1999-2002. doi: 10.1021/jm070088s. Epub 2007 Apr 6.
We have identified five derivatives of the natural product sansalvamide A that are potent against multiple drug-resistant colon cancer cell lines. These analogs share no structural homology to current colon cancer drugs, are cytotoxic at levels on par with existing drugs treating other cancers, and demonstrate selectivity for drug-resistant colon cancer cell lines over noncancerous cell lines. Thus, we have established sansalvamide A as a privileged structure for treating multiple drug-resistant colon cancers.
我们已经鉴定出天然产物无叶假木贼酰胺A的五种衍生物，它们对多种耐药结肠癌细胞系具有强效作用。这些类似物与目前的结肠癌药物没有结构同源性，其细胞毒性水平与治疗其他癌症的现有药物相当，并且对耐药结肠癌细胞系显示出比对非癌细胞系的选择性。因此，我们已将无叶假木贼酰胺A确立为治疗多种耐药结肠癌的优势结构。
Zotero 插件