Chee Michael W L, Chuah Lisa Y M
Cognitive Neuroscience Laboratory, Duke-NUS Graduate Medical School, Singapore.
Curr Opin Neurol. 2008 Aug;21(4):417-23. doi: 10.1097/WCO.0b013e3283052cf7.
The review summarizes current knowledge about what fMRI has revealed regarding the neurobehavioral correlates of sleep deprivation and sleep-dependent memory consolidation.
Functional imaging studies of sleep deprivation have characterized its effects on a number of cognitive domains, the best studied of these being working memory. There is a growing appreciation that it is important to consider interindividual differences in vulnerability to sleep deprivation, task and task difficulty when interpreting imaging results. Our understanding of the role of sleep and the dynamic evolution of offline memory consolidation has benefited greatly from human imaging studies. Both hippocampal-dependent and hippocampal-independent memory systems have been studied.
Functional imaging studies contrasting sleep-deprived and well-rested brains provide substantial evidence that sleep is highly important for optimal cognitive function and learning. The experimental paradigms developed to date merit evaluation in clinical settings to determine the impact of sleep disruption in sleep disorders.
本综述总结了功能磁共振成像（fMRI）在睡眠剥夺与睡眠依赖记忆巩固的神经行为相关性方面所揭示的当前知识。
睡眠剥夺的功能成像研究已描述了其对多个认知领域的影响，其中研究最多的是工作记忆。人们越来越认识到，在解释成像结果时，考虑个体对睡眠剥夺的易感性、任务及任务难度的个体差异很重要。人类成像研究极大地增进了我们对睡眠的作用以及离线记忆巩固的动态演变的理解。海马依赖和海马独立的记忆系统均已得到研究。
对比睡眠剥夺和充分休息大脑的功能成像研究提供了大量证据，表明睡眠对最佳认知功能和学习非常重要。迄今为止开发的实验范式值得在临床环境中进行评估，以确定睡眠障碍中睡眠中断的影响。
