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血管活性肠肽，从基因到行为再回归：总结我25年的研究历程

VIP, from gene to behavior and back: summarizing my 25 years of research.

作者信息

Gozes Illana

机构信息

Adams Super Center for Brain Studies, The Dr. Diana and Zelman Elton Elbaum Laboratory for Molecular Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel.

出版信息

J Mol Neurosci. 2008 Nov;36(1-3):115-24. doi: 10.1007/s12031-008-9105-3. Epub 2008 Jul 8.

DOI:10.1007/s12031-008-9105-3
PMID:18607776
Abstract

Vasoactive intestinal peptide (VIP) is an interesting example of a 28-amino acid neuropeptide that is abundantly expressed in discrete brain regions/neurons and hence may contribute to brain function. This short review summarizes my own point of view and encompasses 25 years of work and over 100 publications targeting the understanding of VIP production and biological activity. The review starts with our original cloning of the VIP gene, it then continues to discoveries of regulation of VIP synthesis and the establishment of the first VIP transgenic mice. The review ends with the identification of novel VIP analogs that helped decipher VIP's important role during development, in regulation of the biological clock(s) and diurnal rhythms, sexual activity, learning and memory as well as social behavior, and cancer. This review cites only articles that I have coauthored and gives my own perspective of this exciting ever-growing field.

摘要

血管活性肠肽（VIP）是一种由28个氨基酸组成的神经肽，它在离散的脑区/神经元中大量表达，因此可能对脑功能有贡献，是一个有趣的例子。这篇简短的综述总结了我自己的观点，涵盖了25年的工作以及100多篇旨在了解VIP产生和生物活性的出版物。综述从我们最初克隆VIP基因开始，接着讲述了VIP合成调控的发现以及首批VIP转基因小鼠的建立。综述最后介绍了新型VIP类似物的鉴定，这些类似物有助于阐明VIP在发育过程、生物钟和昼夜节律调节、性活动、学习和记忆以及社会行为和癌症中的重要作用。这篇综述仅引用了我共同撰写的文章，并给出了我对这个令人兴奋且不断发展的领域的个人观点。

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VIP, from gene to behavior and back: summarizing my 25 years of research.血管活性肠肽，从基因到行为再回归：总结我25年的研究历程
J Mol Neurosci. 2008 Nov;36(1-3):115-24. doi: 10.1007/s12031-008-9105-3. Epub 2008 Jul 8.
2
Characterization of novel splice variants of the PAC1 receptor in human neuroblastoma cells: consequences for signaling by VIP and PACAP.人神经母细胞瘤细胞中PAC1受体新型剪接变体的表征：对血管活性肠肽（VIP）和垂体腺苷酸环化酶激活肽（PACAP）信号传导的影响
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Select cognitive deficits in vasoactive intestinal peptide deficient mice.血管活性肠肽缺陷小鼠的选择性认知缺陷。
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The Neuropeptide VIP Limits Human Osteoclastogenesis: Clinical Associations with Bone Metabolism Markers in Patients with Early Arthritis.神经肽血管活性肠肽限制人类破骨细胞生成：与早期关节炎患者骨代谢标志物的临床关联
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