与低级别子宫内膜样癌和增殖期子宫内膜相比，子宫内膜浆液性癌中基质金属蛋白酶-2（MMP-2）、金属蛋白酶组织抑制因子-1（TIMP-1）、E-钙黏蛋白和β-连环蛋白的表达情况。
MMP-2, TIMP-1, E-cadherin, and beta-catenin expression in endometrial serous carcinoma compared with low-grade endometrial endometrioid carcinoma and proliferative endometrium.
作者信息
Shaco-Levy Ruthy, Sharabi Shalom, Piura Benjamin, Sion-Vardy Netta
机构信息
Department of Pathology, Soroka University Medical Center and Faculty of Health Sciences, Beer-Sheva, Israel.
出版信息
Acta Obstet Gynecol Scand. 2008;87(8):868-74. doi: 10.1080/00016340802253775.
OBJECTIVE
To investigate the expression of MMP-2, TIMP-1, E-cadherin and beta-catenin in endometrial serous carcinoma (ESC), low-grade endometrial endometrioid carcinoma (EEC), and proliferative endometrium.
METHODS
We performed an immunohistochemical study on 14 cases of ESC, 15 cases of low-grade EEC, and 10 cases of proliferative endometrium.
RESULTS
Compared with low-grade EEC, ESC showed significantly increased MMP-2 and TIMP-1 expression, as well as decreased membranous beta-catenin staining. E-cadherin expression was significantly lower in ESC and EEC as compared with proliferative endometrium.
CONCLUSIONS
We suggest that MMP-2 and TIMP-1 expression and loss of beta-catenin have a role in the pathogenesis and progression of ESC. Decreased E-cadherin may have an important role in the development of both ESC and EEC. Furthermore, the dissimilarities in MMP-2, TIMP-1, E-cadherin and beta-catenin expressions in ESC compared with EEC may be responsible, along with other factors, for their different biological behavior.
目的
研究基质金属蛋白酶-2（MMP-2）、基质金属蛋白酶组织抑制因子-1（TIMP-1）、E-钙黏蛋白和β-连环蛋白在子宫内膜浆液性癌（ESC）、低级别子宫内膜样腺癌（EEC）及增殖期子宫内膜中的表达情况。
方法
对14例ESC、15例低级别EEC及10例增殖期子宫内膜进行免疫组织化学研究。
结果
与低级别EEC相比，ESC中MMP-2和TIMP-1表达显著增加，同时β-连环蛋白膜染色减少。与增殖期子宫内膜相比，ESC和EEC中E-钙黏蛋白表达显著降低。
结论
我们认为MMP-2和TIMP-1的表达以及β-连环蛋白的缺失在ESC的发病机制及进展中起作用。E-钙黏蛋白表达降低可能在ESC和EEC的发生发展中起重要作用。此外，与EEC相比，ESC中MMP-2、TIMP-1、E-钙黏蛋白和β-连环蛋白表达的差异可能与其他因素一起导致了它们不同的生物学行为。
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