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E-钙黏蛋白在增生期子宫内膜中的表达：一项回顾性分析。

Expression of E-cadherin in Hyperplastic Endometrium: A Retrospective Analysis.

作者信息

Jayaraman Monisha Rita, En Niveditha, Harikrishnan Volga

机构信息

Pathology, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.

出版信息

Cureus. 2024 Jul 23;16(7):e65225. doi: 10.7759/cureus.65225. eCollection 2024 Jul.

DOI:10.7759/cureus.65225
PMID:39184723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11341771/
Abstract

Aim Epithelial cadherin or E-cadherin is a cell adhesion molecule that is present in all cells to promote integrity and survival of the cells. The aim of this study was to assess the immunohistochemical staining pattern of E-cadherin in hyperplastic endometrium. Methods A total of 25 blocks of formalin-fixed paraffin-embedded tissues of endometrial biopsies, from September 2020 to May 2023, were obtained from the Department of Pathology, Saveetha Medical College. Out of these 25 histologically proven cases of endometrial hyperplasia (EH), 17 cases were of EH without atypia and 8 cases were of endometrial hyperplasia with atypia (AH, or atypical hyperplasia). Results The immunohistochemical examination revealed that E-cadherin expression was downregulated in both EH without atypia and AH. But the downregulation was more pronounced in cases of AH than in EH without atypia. This was confirmed by the comparison of E-cadherin expression between EH with and without atypia by a chi-square test, which showed a p-value of 0.05 and was proven significant. Conclusion The heterogeneous expression of E-cadherin can be attributed to the impairment of cadherin-catenin complex. This impairment is seen in AH as well as EH without atypia. This shows this impairment occurs very early in the transformation process of the endometrium from hyperplastic to neoplastic.

摘要

目的 上皮钙黏蛋白或E-钙黏蛋白是一种存在于所有细胞中的细胞黏附分子，可促进细胞的完整性和存活。本研究的目的是评估E-钙黏蛋白在增生期子宫内膜中的免疫组织化学染色模式。方法 从2020年9月至2023年5月，从萨维塔医学院病理科获取了25例福尔马林固定石蜡包埋的子宫内膜活检组织块。在这25例经组织学证实的子宫内膜增生（EH）病例中，17例为无不典型增生的EH，8例为不典型增生（AH，或非典型增生）的子宫内膜增生。结果 免疫组织化学检查显示，E-钙黏蛋白表达在无不典型增生的EH和AH中均下调。但这种下调在AH病例中比在无不典型增生的EH中更明显。通过卡方检验比较有和无不典型增生的EH之间的E-钙黏蛋白表达，证实了这一点，其p值为0.05，具有统计学意义。结论 E-钙黏蛋白的异质性表达可归因于钙黏蛋白-连环蛋白复合物的损伤。这种损伤在AH以及无不典型增生的EH中均可见。这表明这种损伤在子宫内膜从增生性向肿瘤性转化的过程中很早就发生了。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/11341771/065564d80153/cureus-0016-00000065225-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/11341771/9a9889877475/cureus-0016-00000065225-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/11341771/a42708f39737/cureus-0016-00000065225-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/11341771/2470d37c1eac/cureus-0016-00000065225-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/11341771/42f63aac9f77/cureus-0016-00000065225-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/11341771/876f8fc52876/cureus-0016-00000065225-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/11341771/ba602980b953/cureus-0016-00000065225-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/11341771/065564d80153/cureus-0016-00000065225-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/11341771/9a9889877475/cureus-0016-00000065225-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/11341771/a42708f39737/cureus-0016-00000065225-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/11341771/2470d37c1eac/cureus-0016-00000065225-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/11341771/42f63aac9f77/cureus-0016-00000065225-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/11341771/876f8fc52876/cureus-0016-00000065225-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/11341771/ba602980b953/cureus-0016-00000065225-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b28/11341771/065564d80153/cureus-0016-00000065225-i07.jpg

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本文引用的文献

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Arch Gynecol Obstet. 2022 Aug;306(2):407-421. doi: 10.1007/s00404-021-06380-5. Epub 2022 Jan 10.
2
Expression level of E-, N- and P-cadherin proteins in endometrial cancer.子宫内膜癌中E-钙黏蛋白、N-钙黏蛋白和P-钙黏蛋白的蛋白表达水平。
Oncol Lett. 2021 Apr;21(4):261. doi: 10.3892/ol.2021.12522. Epub 2021 Feb 4.
3
Could E-Cadherin and CD10 Expression be Used to Differentiate Between Atypical Endometrial Hyperplasia and Endometrial Carcinoma?
E-钙黏蛋白和CD10的表达能否用于鉴别非典型子宫内膜增生和子宫内膜癌？
Int J Gynecol Pathol. 2019 Mar;38(2):128-137. doi: 10.1097/PGP.0000000000000492.
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Atypical Endometrial Hyperplasia and Well Differentiated Endometrioid Adenocarcinoma of the Uterine Corpus.子宫体非典型子宫内膜增生及高分化子宫内膜样腺癌
Surg Pathol Clin. 2011 Mar;4(1):149-98. doi: 10.1016/j.path.2010.12.007. Epub 2011 Feb 22.
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E-cadherin and CD10 expression in atypical hyperplastic and malignant endometrial lesions.E-钙黏蛋白和CD10在非典型增生性和恶性子宫内膜病变中的表达。
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Predicting the coexistence of an endometrial adenocarcinoma in the presence of atypical complex hyperplasia: immunohistochemical analysis of endometrial samples.预测存在非典型复杂增生的子宫内膜腺癌的共存：子宫内膜样本的免疫组织化学分析。
Int J Gynecol Cancer. 2012 Sep;22(7):1264-72. doi: 10.1097/IGC.0b013e31826302a3.
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E-cadherin and alpha-catenin expression in normal, hyperplastic and neoplastic endometrium.正常、增生和肿瘤子宫内膜中 E-钙黏蛋白和α-连环蛋白的表达。
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