Kimberg Matti, Brown Gordon D
Institute of Infectious Disease and Molecular Medicine, Division of Immunology, University of Cape Town, Observatory, Cape Town, South Africa.
Med Mycol. 2008 Nov;46(7):631-6. doi: 10.1080/13693780802140907.
The innate recognition of fungal pathogens is mediated by a variety of pattern recognition receptors (PRRs), although much interest has focussed on the Toll-like Receptors (TLR). More recently, however, there is growing appreciation that the non-TLRs have a major role in the control of infection with these organisms. One such molecule is Dectin-1, a C-type lectin-like receptor which induces numerous cellular responses upon recognition of fungal beta-glucans. Here we review our current understanding of the functions of Dectin-1 and the underlying molecular mechanisms, as well as explore the role of this receptor in antifungal immunity.
真菌病原体的天然识别由多种模式识别受体（PRR）介导，尽管人们的很多兴趣都集中在Toll样受体（TLR）上。然而，最近人们越来越认识到非TLR在控制这些病原体感染中起主要作用。其中一种分子是Dectin-1，它是一种C型凝集素样受体，在识别真菌β-葡聚糖后可诱导多种细胞反应。在此，我们综述了目前对Dectin-1功能及其潜在分子机制的理解，并探讨了该受体在抗真菌免疫中的作用。
