Tsoni S Vicky, Brown Gordon D
Division of Immunology, CLS, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Ann N Y Acad Sci. 2008 Nov;1143:45-60. doi: 10.1196/annals.1443.019.
beta-Glucans are naturally occurring carbohydrates that possess immune-modulating activities, but their mechanisms of action are largely unknown. Recent discoveries, however, including identification of beta-glucan receptors, such as dectin-1, have started to shed some light on the mechanisms underlying the properties of these carbohydrates. The characterization of dectin-1, in particular, has revealed some of the processes involved in beta-glucan sensing, intracellular signaling, and induction of cellular responses and has provided new insights into the role of beta-glucans in immunity and disease. Here we review both beta-glucans and their receptor, dectin-1.
β-葡聚糖是具有免疫调节活性的天然存在的碳水化合物，但其作用机制在很大程度上尚不清楚。然而，最近的发现，包括β-葡聚糖受体（如dectin-1）的鉴定，已开始揭示这些碳水化合物特性背后的一些机制。特别是dectin-1的特性，揭示了β-葡聚糖感知、细胞内信号传导以及细胞反应诱导过程中的一些情况，并为β-葡聚糖在免疫和疾病中的作用提供了新的见解。在此，我们综述β-葡聚糖及其受体dectin-1。
