Capone Federico, Vacca Antonio, Bidault Guillaume, Sarver Dylan, Kaminska Dorota, Strocchi Stefano, Vidal-Puig Antonio, Greco Carolina M, Lusis Aldons J, Schiattarella Gabriele G
Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany (F.C., A.V., S.S., G.G.S.).
Department of Medicine, Unit of Internal Medicine III, Padua University Hospital, University of Padua, Padova, Italy (F.C.).
Circ Res. 2025 May 23;136(11):1335-1362. doi: 10.1161/CIRCRESAHA.125.325492. Epub 2025 May 22.
The liver and heart are closely interconnected organs, and their bidirectional interaction plays a central role in cardiometabolic disease. In this review, we summarize current evidence linking liver dysfunction-particularly metabolic dysfunction-associated steatotic liver disease, alcohol-associated liver disease, and cirrhosis-with an increased risk of heart failure and other cardiovascular diseases. We discuss how these liver conditions contribute to cardiac remodeling, systemic inflammation, and hemodynamic stress and how cardiac dysfunction in turn impairs liver perfusion and promotes hepatic injury. Particular attention is given to the molecular mediators of liver-heart communication, including hepatokines and cardiokines, as well as the emerging role of advanced research methodologies, including omics integration, proximity labeling, and organ-on-chip platforms, that are redefining our understanding of interorgan cross talk. By integrating mechanistic insights with translational tools, this review aims to support the development of multiorgan therapeutic strategies for cardiometabolic disease.
肝脏和心脏是紧密相连的器官，它们之间的双向相互作用在心脏代谢疾病中起着核心作用。在这篇综述中，我们总结了当前将肝功能障碍（特别是代谢功能障碍相关脂肪性肝病、酒精性肝病和肝硬化）与心力衰竭及其他心血管疾病风险增加联系起来的证据。我们讨论了这些肝脏疾病如何导致心脏重塑、全身炎症和血流动力学应激，以及心脏功能障碍如何反过来损害肝脏灌注并促进肝损伤。我们特别关注肝脏与心脏通信的分子介质，包括肝脏因子和心脏因子，以及先进研究方法（包括组学整合、邻近标记和芯片器官平台）的新作用，这些方法正在重新定义我们对器官间相互作用的理解。通过将机制见解与转化工具相结合，本综述旨在支持心脏代谢疾病多器官治疗策略的开发。
