Department of Child and Adolescent Psychiatry, University Medical Center, Utrecht, and the Rudolph Magnus Institute of Neurosciences, The Netherlands.
World J Biol Psychiatry. 2009;10(4 Pt 3):905-12. doi: 10.1080/15622970801901828.
Multiple complex developmental disorder (MCDD) is a well-defined and validated behavioural subtype of pervasive developmental disorder-not otherwise specified (PDD-NOS) and is thought to be associated with a higher risk of developing a schizophrenic spectrum disorder. The question was addressed whether patients with MCDD show the same psychophysiological abnormalities as seen in patients with schizophrenia.
Smooth pursuit eye movement (pursuit gain and saccadic parameters) was measured in children with either MCDD (n=18) or autism (n=18), and in age- and IQ-matched controls (n=36), as well as in a group of adult patients with schizophrenia (n=14) and a group of adult controls (n=17).
We found the expected effect of lower velocity gain and increased number of saccades in schizophrenic patients. Children with MCDD also showed a lower velocity gain compared to controls children. In contrast, velocity gain was similar in autistic subjects and controls. No differences for velocity gain were found in a direct comparison between MCDD and autism. Saccadic parameters were not significantly different from controls in either MCDD or autistic subjects.
Children with MCDD, like schizophrenic adults, show a reduced velocity gain, which could indicate that schizophrenia spectrum disorders and MCDD share (at least to some degree) a common neurobiological background.
多种复杂发育障碍（MCDD）是一种明确且经过验证的广泛性发育障碍未特定型（PDD-NOS）的行为亚型，被认为与发展为精神分裂症谱系障碍的风险较高有关。问题是 MCDD 患者是否表现出与精神分裂症患者相同的心理生理异常。
在 MCDD（n=18）或自闭症（n=18）患儿、年龄和智商匹配的对照组（n=36），以及一组成年精神分裂症患者（n=14）和一组成年对照组（n=17）中测量了平滑追踪眼动（追踪增益和扫视参数）。
我们发现精神分裂症患者的预期效应是速度增益降低和扫视次数增加。与对照组儿童相比，MCDD 患儿的速度增益也较低。相比之下，自闭症患者的速度增益与对照组相似。在 MCDD 与自闭症之间的直接比较中，速度增益没有差异。在 MCDD 或自闭症患者中，扫视参数与对照组相比没有显著差异。
MCDD 患儿与成年精神分裂症患者一样，表现出速度增益降低，这表明精神分裂症谱系障碍和 MCDD 至少在某种程度上具有共同的神经生物学基础。
