Buitelaar J K, van der Gaag R J
Department of Child Psychiatry and the Rudolph Magnus Institute for Neurosciences, Utrecht, The Netherlands.
J Child Psychol Psychiatry. 1998 Sep;39(6):911-9.
This study was designed to examine the classification performance of diagnostic rules for pervasive developmental disorder not otherwise specified (PDD-NOS) and multiple complex developmental disorder (McDD), with clinical diagnosis as the gold standard. McDD is an heuristic concept of a developmental disorder characterised by social impairments, affective dysregulation, and thought disturbance. Detailed information on the symptoms, reliably extracted from the charts of 103 children with PDD-NOS and McDD, 32 with autistic disorder, and 96 with non-PDD disorders, was used to determine the presence of the DSM-IV criteria of autistic disorder and the criteria of McDD. A scoring rule for PDD-NOS based on a short set of seven DSM-IV criteria with a cut-off point of three items and one social interaction item set as mandatory had the best balance between high sensitivity and high specificity. The most effective and simple rule based on McDD criteria had a cut-off of three items, out of six items of anxieties and thought disturbance.
本研究旨在以临床诊断为金标准，检验未特定的广泛性发育障碍（PDD-NOS）和多重复杂发育障碍（McDD）诊断规则的分类性能。McDD是一种启发式的发育障碍概念，其特征为社交障碍、情感失调和思维紊乱。从103例PDD-NOS和McDD患儿、32例孤独症谱系障碍患儿以及96例非PDD障碍患儿的病历中可靠提取的详细症状信息，用于确定孤独症谱系障碍的DSM-IV标准及McDD标准的存在情况。基于一组简短的七个DSM-IV标准制定的PDD-NOS评分规则，以三项及一项社交互动项目为强制标准作为截断点，在高敏感性和高特异性之间取得了最佳平衡。基于McDD标准的最有效且简单的规则，在六项焦虑和思维紊乱项目中有三项作为截断点。
