Asimakopoulou Athanasia P, Theocharis Achilleas D, Tzanakakis George N, Karamanos Nikos K
Department of Chemistry, Laboratory of Biochemistry, University of Patras, Greece.
In Vivo. 2008 May-Jun;22(3):385-9.
Chondroitin sulfate proteoglycans (CSPGs) such as versican accumulate in tumor stroma and play a key role in tumor growth and invasion. The high expression of CSPGs in fast growing tissues and cells is correlated with chondroitin sulfate (CS) chains and the sulfation pattern. The negatively charged CS chains interact with a large number of ligands and receptors and activate signalling pathways which stimulate tumor growth. However, the role of chondroitin sulfate in cancer promotion seems to be controversial, as recent studies support the use of modified CS as a potent anticancer agent. In this review, the biological roles of CSPGs in cancer and the anticancer effects of modified CS are presented and discussed.
硫酸软骨素蛋白聚糖（CSPG），如多功能蛋白聚糖，在肿瘤基质中积聚，并在肿瘤生长和侵袭中起关键作用。CSPG在快速生长的组织和细胞中的高表达与硫酸软骨素（CS）链及硫酸化模式相关。带负电荷的CS链与大量配体和受体相互作用，并激活刺激肿瘤生长的信号通路。然而，硫酸软骨素在癌症促进中的作用似乎存在争议，因为最近的研究支持将修饰的CS用作有效的抗癌剂。在本综述中，将介绍并讨论CSPG在癌症中的生物学作用以及修饰的CS的抗癌作用。
