丁丙诺啡和安非他酮用于阿片类药物依赖吸烟者的初步研究。
Preliminary study of buprenorphine and bupropion for opioid-dependent smokers.
作者信息
Mooney Marc E, Poling James, Gonzalez Gerardo, Gonsai Kishor, Kosten Thomas, Sofuoglu Mehmet
机构信息
Department of Psychiatry, Transdisciplinary Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota 55414, USA.
出版信息
Am J Addict. 2008 Jul-Aug;17(4):287-92. doi: 10.1080/10550490802138814.
Abstract
In this double-blind, placebo-controlled trial, bupropion (BUPRO, 300 mg/day) was compared to placebo (PBO) for the concurrent treatment of opioid and tobacco addiction in 40 opioid-dependent smokers stabilized on buprenorphine (BUPRE, 24 mg/day). Participants received contingent, monetary reinforcement for abstinence from smoking, illicit opioids, and cocaine. Significant differences in treatment retention were observed (BUPRE+BUPRO, 58%; BUPRE+PBO, 90%). BUPRO treatment was not more effective than placebo for abstinence from tobacco, opioids, or cocaine in BUPRE-stabilized patients. These preliminary findings do not support the efficacy of BUPRO, in combination with BUPRE, for the concurrent treatment of opioid and tobacco addiction.
摘要
在这项双盲、安慰剂对照试验中，将安非他酮（BUPRO，300毫克/天）与安慰剂（PBO）进行比较，以同时治疗40名依赖阿片类药物且已使用丁丙诺啡（BUPRE，24毫克/天）稳定治疗的吸烟者的阿片类药物和烟草成瘾问题。参与者因戒烟、戒除非法阿片类药物和可卡因而获得意外的金钱奖励。观察到治疗保留率存在显著差异（BUPRE+BUPRO组为58%；BUPRE+PBO组为90%）。在使用BUPRE稳定治疗的患者中，BUPRO治疗在戒烟、戒除阿片类药物或可卡因方面并不比安慰剂更有效。这些初步研究结果不支持BUPRO与BUPRE联合用于同时治疗阿片类药物和烟草成瘾的疗效。
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