通过对N-保护的氮丙啶进行α-去质子化/亲电试剂捕获来合成末端氮丙啶。
Terminal aziridines by alpha-deprotonation/electrophile trapping of N-protected aziridine.
作者信息
Hodgson David M, Hughes Steven P, Thompson Amber L, Heightman Tom D
机构信息
Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
出版信息
Org Lett. 2008 Aug 21;10(16):3453-6. doi: 10.1021/ol801224g. Epub 2008 Jul 10.
PMID:18613698
Abstract
N-tert-Butylsulfonyl and N-tert-butylsulfinyl aziridine undergo alpha-lithiation/electrophile trapping providing a new entry to terminal aziridines. With N-tert-butylsulfinyl aziridine complete asymmetric induction is observed alpha to nitrogen.
摘要
N-叔丁基磺酰基氮丙啶和N-叔丁基亚磺酰基氮丙啶发生α-锂化/亲电试剂捕获反应，为合成末端氮丙啶提供了一条新途径。对于N-叔丁基亚磺酰基氮丙啶，在氮的α位观察到了完全的不对称诱导。
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