Lunts V Ia
Biull Eksp Biol Med. 1976 Sep;82(9):1055-9.
The effect of 24 imidazol derivatives on the activity of phosphodiesterase (3', 5'-AMP-phosphohydrolase; KF3.1.4.1) was studied in the experiments with the homogenates of the rat brain and of the Rana temporaria skeletal muscles. Imidazol derivatives could produce both the activating and inhibitory influence on the enzyme. Imidazol and seven of its alkyl-substituted derivatives activated the phosphodiesterase. TTFB (tetrachloro-2-trifluoromethylbenzimidazol) produced the greatest inhibitory effect among the inhibitors on the phosphodiesterase activity.
在对大鼠脑匀浆和林蛙骨骼肌匀浆进行的实验中，研究了24种咪唑衍生物对磷酸二酯酶（3',5'-AMP磷酸水解酶；KF3.1.4.1）活性的影响。咪唑衍生物对该酶可产生激活和抑制作用。咪唑及其7种烷基取代衍生物激活了磷酸二酯酶。在这些抑制剂中，四氯-2-三氟甲基苯并咪唑（TTFB）对磷酸二酯酶活性的抑制作用最强。
