Ashe W K, Notkins A L
Laboratory of Microbiology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA.
Virology. 1967 Dec;33(4):613-7. doi: 10.1016/0042-6822(67)90061-x.
Incubation of herpes simplex virus (HSV) with rabbit anti-HSV for as little as 2.5 minutes rendered 75% of the surviving fraction neutralizable by anti-rabbit-gamma-globulin antiserum. The degree of this sensitization increased with time and at 20 minutes over 99.8% of the surviving virus was sensitized. Neutralization kinetics showed that as the degree of sensitization increased, the neutralization rate constant decreased. Incubation of HSV with anti-HSV for 5, 20, and 120 minutes resulted, respectively, in a 23%, 59%, and 87% reduction in the neutralization rate constant. These findings suggest that sensitization is an important factor in the inhibition of neutralization and the formation of the persistent fraction.
单纯疱疹病毒（HSV）与兔抗HSV孵育仅2.5分钟，就使75%的存活病毒可被抗兔γ球蛋白抗血清中和。这种致敏程度随时间增加，在20分钟时，超过99.8%的存活病毒被致敏。中和动力学表明，随着致敏程度增加，中和速率常数降低。HSV与抗HSV分别孵育5、20和120分钟后，中和速率常数分别降低了23%、59%和87%。这些发现表明，致敏是抑制中和作用和形成持续感染部分的一个重要因素。
