在前一天进行耐力运动后，摄入高糖食物后的内皮功能会得到改善。
Endothelial function after high-sugar-food ingestion improves with endurance exercise performed on the previous day.
作者信息
Weiss Edward P, Arif Hassan, Villareal Dennis T, Marzetti Emanuele, Holloszy John O
机构信息
Department of Internal Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
出版信息
Am J Clin Nutr. 2008 Jul;88(1):51-7. doi: 10.1093/ajcn/88.1.51.
BACKGROUND
Endothelial function deteriorates after glucose ingestion. This may be attributed to hyperglycemia-induced oxidative stress. Acute endurance exercise might improve postprandial endothelial function by enhancing glucoregulation and reducing postprandial hyperglycemia.
OBJECTIVE
The objective was to determine whether endurance exercise performed 17 h before high-sugar-food ingestion attenuates postprandial impairment in endothelial function.
DESIGN
Healthy men and women (n = 13; age: 48 +/- 17 y) were studied on 2 occasions: after > or = 48 h with no exercise and 17 h after a 60-min bout of endurance exercise. During each trial, brachial artery flow mediated dilation (FMD) was used to assess endothelial function before and after the ingestion of a candy bar and soft drink. Glucose, insulin, and thiobarbituric acid-reactive substances (TBARS), a marker of oxidative stress, were measured in blood obtained during each FMD measurement. The insulin sensitivity index was calculated from the glucose and insulin data.
RESULTS
FMD decreased significantly after food ingestion in both trials. However, prior exercise shifted the entire FMD curve upward (main treatment effect: P = 0.0002), which resulted in a greater area under the curve for FMD (774 +/- 122%.min) than did no exercise (607 +/- 122%.min) (P = 0.01). Prior exercise shifted the glucose and insulin curves downward (main treatment effects: P = 0.05 and P = 0.0007, respectively) and resulted in a significantly greater insulin sensitivity index (10.8 +/- 0.7) than did no exercise (9.2 +/- 0.7) (P = 0.01). TBARS did not differ significantly between trials.
CONCLUSION
Postprandial endothelial function was improved by endurance exercise performed approximately 17 h earlier. This effect was accompanied by exercise-induced improvements in insulin action and reductions in glycemia, but did not correspond with reductions in oxidative stress, as assessed by TBARS.
背景
摄入葡萄糖后内皮功能会恶化。这可能归因于高血糖诱导的氧化应激。急性耐力运动可能通过增强血糖调节和降低餐后高血糖来改善餐后内皮功能。
目的
确定在摄入高糖食物前17小时进行耐力运动是否能减轻餐后内皮功能损害。
设计
对13名健康男性和女性（年龄：48±17岁）进行了两次研究：一次是在≥48小时不运动后，另一次是在进行60分钟耐力运动后17小时。在每次试验期间，在摄入一块糖果和一杯软饮料前后，使用肱动脉血流介导的舒张功能（FMD）来评估内皮功能。在每次FMD测量时采集的血液中测量葡萄糖、胰岛素和氧化应激标志物硫代巴比妥酸反应性物质（TBARS）。根据葡萄糖和胰岛素数据计算胰岛素敏感性指数。
结果
在两次试验中，摄入食物后FMD均显著降低。然而，之前的运动使整个FMD曲线向上移动（主要治疗效果：P = 0.0002），这导致FMD曲线下面积（774±122%·分钟）大于不运动时（607±122%·分钟）（P = 0.01）。之前的运动使葡萄糖和胰岛素曲线向下移动（主要治疗效果：分别为P = 0.05和P = 0.0007），并导致胰岛素敏感性指数（10.8±0.7）显著高于不运动时（9.2±0.7）（P = 0.01）。两次试验中TBARS无显著差异。
结论
提前约17小时进行的耐力运动改善了餐后内皮功能。这种效果伴随着运动诱导的胰岛素作用改善和血糖降低，但与通过TBARS评估的氧化应激降低无关。
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