Shiloh S, Koehly L, Jenkins J, Martin J, Hadley D
Psychology Department, Tel Aviv University, Tel Aviv, Israel.
Psychooncology. 2008 Aug;17(8):746-55. doi: 10.1002/pon.1338.
The emotional effects of genetic testing for hereditary nonpolyposis colorectal cancer (HNPCC) provided within a counseling program were assessed among 253 individuals.
Assessments were scheduled at baseline before testing, and again after 6 and 12 months post-test. Negative emotional reactions were evaluated using the Revised Impact of Event Scale and the Center for Epidemiological Studies-Depression Scale. Monitoring coping style was assessed at baseline using the Miller Behavioral Style Scale.
Mean reductions were indicated in distress and depression levels within the first 6 months after counseling and testing. High monitors were generally more distressed than low monitors, specifically if they had indeterminate or positive results.
Genetic counseling and testing for HNPCC do not result in long-term distress for most people. Of the variables investigated, only time and coping style have main effects on emotional reactions, and the impacts of mutation status are moderated by coping style. Psychological interventions, aimed to alleviate adverse emotional effects, were suggested for certain participants, i.e. recipients of positive or indeterminate results who are high monitors.
在253名个体中评估了遗传咨询项目中针对遗传性非息肉病性结直肠癌（HNPCC）进行基因检测所产生的情绪影响。
在检测前的基线期以及检测后6个月和12个月再次进行评估。使用修订版事件影响量表和流行病学研究中心抑郁量表评估负面情绪反应。在基线期使用米勒行为风格量表评估监测应对方式。
咨询和检测后的前6个月内，痛苦和抑郁水平均有下降。高监测者通常比低监测者更痛苦，特别是当他们的检测结果为不确定或阳性时。
对大多数人而言，HNPCC的遗传咨询和检测不会导致长期痛苦。在所研究的变量中，只有时间和应对方式对情绪反应有主要影响，而突变状态的影响会因应对方式而缓和。建议对某些参与者，即检测结果为阳性或不确定的高监测者进行心理干预，以减轻不良情绪影响。
