Shi Qing, Ye Shuji, Kristalyn Cornelius, Su Yanlei, Jiang Zhongyi, Chen Zhan
Key Laboratory for Green Chemical Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Langmuir. 2008 Aug 5;24(15):7939-46. doi: 10.1021/la800570a. Epub 2008 Jul 11.
We blended Pluronic F127 into polyethersulfone (PES) to improve surface properties of PES, which has been extensively used in biomaterial and other applications. The molecular surface structures of PES/Pluronic F127 blends have been investigated by sum-frequency generation (SFG) vibrational spectroscopy. The molecular orientation of surface functional groups of PES changed significantly when blended with a small amount of Pluornic F127. Pluronic F127 on the blend surface also exhibited different features upon contacting with water. The entanglement of PES chains with Pluronic F127 molecules rendered the blends with long-term surface stability in water in contrast to the situation where a layer of Pluronic F127 adsorbed on the PES surface. Atomic force microscopy (AFM) and quartz crystal microbalance (QCM) measurements were included to determine the relative amount of protein that adsorbed to the blend surfaces. The results showed a decreased protein adsorption amount with increasing Pluronic F127 bulk concentration. The correlations between polymer surface properties and detailed molecular structures obtained by SFG would provide insight into the designing and developing of biomedical polymers and functional membranes with improved fouling-resistant properties.
我们将普朗尼克F127混入聚醚砜（PES）中，以改善PES的表面性能，PES已广泛应用于生物材料及其他领域。通过和频振动光谱（SFG）对PES/普朗尼克F127共混物的分子表面结构进行了研究。当与少量普朗尼克F127混合时，PES表面官能团的分子取向发生了显著变化。共混物表面的普朗尼克F127在与水接触时也表现出不同的特征。与普朗尼克F127吸附在PES表面的情况相比，PES链与普朗尼克F127分子的缠结使共混物在水中具有长期的表面稳定性。采用原子力显微镜（AFM）和石英晶体微天平（QCM）测量来确定吸附在共混物表面的蛋白质的相对量。结果表明，随着普朗尼克F127本体浓度的增加，蛋白质吸附量减少。通过SFG获得的聚合物表面性能与详细分子结构之间的相关性，将为设计和开发具有更好抗污染性能的生物医学聚合物和功能膜提供思路。
