阿拉斯加爱斯基摩人亚临床动脉粥样硬化的患病率及其相关因素：GOCADAN研究
Prevalence and correlates of subclinical atherosclerosis in Alaska Eskimos: the GOCADAN study.
作者信息
Cutchins Alexis, Roman Mary J, Devereux Richard B, Ebbesson Sven O E, Umans Jason G, Zhu Jianhui, Weissman Neil J, Howard Barbara V
机构信息
Division of Cardiology, Weill Cornell Medical College, New York, NY 10021, USA.
出版信息
Stroke. 2008 Nov;39(11):3079-82. doi: 10.1161/STROKEAHA.108.519199. Epub 2008 Jul 10.
BACKGROUND AND PURPOSE
The recent increase in clinical cardiovascular disease in Alaska Eskimos suggests that changes in traditional lifestyle may have adverse public health consequences. This study examines the prevalence of subclinical vascular disease and its relation to risk factors in Alaska Eskimos.
METHODS
Participants in the population-based Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) Study underwent evaluation of cardiovascular disease risk factors and carotid ultrasound. Outcome variables were carotid intimal-medial thickness and presence and extent of atherosclerosis.
RESULTS
In multivariate analyses, intimal-medial thickness and presence and extent of atherosclerosis were all associated with traditional cardiovascular disease risk factors but not dietary intake of omega-3 fatty acids. Rates of carotid atherosclerosis were higher than those reported in 2 large population-based US studies.
CONCLUSIONS
Alaska Eskimos have similar traditional risk factors for carotid atherosclerosis as other ethnic and racial populations but have higher prevalences of atherosclerosis, possibly attributable to higher rates of smoking.
背景与目的
阿拉斯加爱斯基摩人临床心血管疾病近期有所增加，这表明传统生活方式的改变可能会对公众健康产生不良影响。本研究调查了阿拉斯加爱斯基摩人亚临床血管疾病的患病率及其与危险因素的关系。
方法
基于人群的阿拉斯加原住民冠状动脉疾病遗传学（GOCADAN）研究的参与者接受了心血管疾病危险因素评估和颈动脉超声检查。结局变量为颈动脉内膜中层厚度以及动脉粥样硬化的存在情况和程度。
结果
在多变量分析中，内膜中层厚度以及动脉粥样硬化的存在情况和程度均与传统心血管疾病危险因素相关，但与ω-3脂肪酸的饮食摄入量无关。颈动脉粥样硬化的发生率高于美国两项大型基于人群的研究报告的发生率。
结论
阿拉斯加爱斯基摩人与其他种族人群患颈动脉粥样硬化的传统危险因素相似，但动脉粥样硬化的患病率更高，这可能归因于吸烟率较高。
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