Kromhout D, Bosschieter E B, de Lezenne Coulander C
N Engl J Med. 1985 May 9;312(19):1205-9. doi: 10.1056/NEJM198505093121901.
The low death rate from coronary heart disease among the Greenland Eskimos has been ascribed to their high fish consumption. We therefore decided to investigate the relation between fish consumption and coronary heart disease in a group of men in the town of Zutphen, the Netherlands. Information about the fish consumption of 852 middle-aged men without coronary heart disease was collected in 1960 by a careful dietary history obtained from the participants and their wives. During 20 years of follow-up 78 men died from coronary heart disease. An inverse dose-response relation was observed between fish consumption in 1960 and death from coronary heart disease during 20 years of follow-up. This relation persisted after multiple logistic-regression analyses. Mortality from coronary heart disease was more than 50 per cent lower among those who consumed at least 30 g of fish per day than among those who did not eat fish. We conclude that the consumption of as little as one or two fish dishes per week may be of preventive value in relation to coronary heart disease.
格陵兰爱斯基摩人冠心病死亡率低归因于他们大量食用鱼类。因此，我们决定在荷兰祖特芬镇的一组男性中调查鱼类消费与冠心病之间的关系。1960年，通过仔细询问参与者及其妻子的饮食史，收集了852名无冠心病中年男性的鱼类消费信息。在20年的随访期间，78名男性死于冠心病。观察到1960年的鱼类消费量与20年随访期间冠心病死亡之间存在剂量反应反比关系。经过多重逻辑回归分析，这种关系依然存在。每天至少食用30克鱼的人群中，冠心病死亡率比不食用鱼的人群低50%以上。我们得出结论，每周食用一到两道鱼菜可能对预防冠心病具有价值。
