Chernysheva A, Tsitlidze N M, Savost'ianov K V, Zil'berman L I, Kuraeva T L, Peterkova V A, Dedov I I, Nosikov V V
Genetika. 2008 Feb;44(2):232-5.
To map human chromosome 2 region associated with type 1 diabetes mellitus, 89 families with concordant and discordant sib pairs were analyzed. Linkage and association with type 1 diabetes were examined using polymorphic microsatellite markers spanning the region of about 4 Mb. The linkage plot was constructed, and association of the five microsatellite markers within the chromosomal region 2q35 was examined. Polymorphic marker D2S137 (Z' = 3.225, p(c) = 0.0048) demonstrated maximum linkage and association with type 1 diabetes.
为了绘制与1型糖尿病相关的人类2号染色体区域图谱，对89个有一致和不一致同胞对的家庭进行了分析。使用跨越约4 Mb区域的多态性微卫星标记检查与1型糖尿病的连锁和关联。构建了连锁图谱，并检查了染色体区域2q35内五个微卫星标记的关联。多态性标记D2S137（Z' = 3.225，p(c) = 0.0048）显示出与1型糖尿病的最大连锁和关联。
