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过氧化物酶体:由内质网产生。

Peroxisomes: minted by the ER.

作者信息

Tabak Henk F, van der Zand Adabella, Braakman Ineke

机构信息

Cellular Protein Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands.

出版信息

Curr Opin Cell Biol. 2008 Aug;20(4):393-400. doi: 10.1016/j.ceb.2008.05.008. Epub 2008 Jul 9.

Abstract

Peroxisomes are one of numerous organelles in a eukaryotic cell; they are small, single-membrane-bound vesicles involved in cellular metabolism, particularly fatty acid degradation. Transport of metabolites and co-factors in and across the membrane is taken care of by specific transporters. Peroxisome formation and maintenance has been debated for a long time: opinions swinging from autonomous to ER-derived organelles. Only recently it has been established firmly that the site of origin of peroxisomes is the ER. It implies that a new branch of the endomembrane system is open to further characterization.

摘要

过氧化物酶体是真核细胞中众多细胞器之一;它们是小的、单膜包裹的囊泡,参与细胞代谢,特别是脂肪酸降解。代谢物和辅助因子在膜内外的运输由特定的转运蛋白负责。过氧化物酶体的形成和维持长期以来一直存在争议:观点从自主细胞器到内质网衍生细胞器摇摆不定。直到最近才确凿地确定过氧化物酶体的起源部位是内质网。这意味着内膜系统的一个新分支有待进一步表征。

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